Facilitative effects of bi-hemispheric tDCS in cognitive deficits of Parkinson disease patients




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Details zur Publikation

Autorenliste: Leite J, Goncalves OF, Carvalho S
Verlag: Elsevier
Jahr der Veröffentlichung: 2014
Bandnummer: 82
Heftnummer: 2
Erste Seite: 138
Letzte Seite: 140
Seitenumfang: 3
ISSN: 0306-9877
Sprachen: Englisch-Vereinigtes Königreich (EN-GB)


Parkinson's disease (PD) is a progressive neurodegenerative disorder, primarily characterized by motor symptoms such as tremor, rigidity, bradykinesia, stiffness, slowness and impaired equilibrium. Although the motor symptoms have been the focus in PD, slight cognitive deficits are commonly found in non-demented and non-depressed PD patients, even in early stages of the disease, which have been linked to the subsequent development of pathological dementia. Thus, strongly reducing the quality of life (QoL).Both levodopa therapy and deep brain stimulation (DBS) have yield controversial results concerning the cognitive symptoms amelioration in PD patients. That does not seems to be the case with transcranial direct current stimulation (tDCS), although better stimulation parameters are needed. Therefore we hypothesize that simultaneously delivering cathodal tDCS (or ctDCS), over the right prefrontal cortex delivered with anodal tDCS (or atDCS) to left prefrontal cortex could be potentially beneficial for PD patients, either by mechanisms of homeostatic plasticity and by increases in the extracellular dopamine levels over the striatum. (C) 2013 Elsevier Ltd. All rights reserved.


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Zuletzt aktualisiert 2019-23-08 um 11:15