Startle-response based tasks and laboratory measures of impulsivity in abstinent alcoholic patients.

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Publication Details

Author list: Jurado Barba R
Publisher: Oxford University Press
Publication year: 2015
Journal: Alcohol and alcoholism (Oxford, Oxfordshire) (13586173)
Volume number: 50
Issue number: 3
Start page: 286
End page: 295
Number of pages: 10
ISSN: 13586173
Languages: English-Great Britain (EN-GB)


Abstract

It is well known that impulsivity is a risk factor for the development
of Addictive Disorders, and more specifically Alcohol Use Disorders
(AUD). Recently, the Startle-Response Based Tasks (SRBT) and its
different forms of plasticity have been found to be impaired in the
alcoholic population. This is the first study to explore the correlation
between impulsivity laboratory tasks and the SRBT test, in order to
determine whether impulsivity and startle response (SR) could be related
and in turn, explain their association with Alcohol Dependence (AD).40
men, who met DSM-IV criteria for AD and had been abstinent for at least
one month. Impulsivity was assessed using three laboratory tests:
Continuous Performance Test (CPT), Stop-Signal Task (SST) and
Differential Reinforcement for Low-Rate Responding (DRL6). Patients also
underwent the SR test. They were compared to 40 matched
controls.Impulsivity laboratory measures tasks (SST and commissions of
the CPT) correlated positively with the magnitude of SR (P < 0.05)
and with habituation (P < 0.05). Scores on DRL6 correlated negatively
with the magnitude of SR (P < 0.05). This was not found in the
control group.The fact that impulsivity laboratory measures and the SR
are correlated in patients but not in controls, could imply the
existence of a common link for these two measures in alcoholic patients.
Our findings support the hypothesis of the existence of two different
vulnerability pathways for the development of AUD: anxiety and
disinhibitory behaviour.


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Last updated on 2019-13-08 at 00:45