Startle response and prepulse inhibition in alcohol use disorders. Implications for the clinical practice | La respuesta de sobresalto y la inhibición prepulso en los trastornos por uso de alcohol. Implicaciones para la práctica clínica

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Publication Details

Author list: Jurado Barba R
Publication year: 2014
Volume number: 25
Issue number: 3
Start page: 147
End page: 155
Number of pages: 9
Languages: English-Great Britain (EN-GB), Spanish-Spain (ES-ES)


In recent years, the addictive processes and more specifically Alcohol
Use Disorders (AUD) have been studied using different neuropsychological
and neurophysiological approaches, including the Startle Response (SR)
and the Prepulse Inhibition (PPI). In this article we present the
results of three studies carried out by our group. The first study
included 19 male patients who had alcohol dependence and were detoxified
for a period of 10-14 days, undergoing testing for SR and PPI at
baseline and after the detoxification treatment. The second study
included 60 abstinent alcoholic men who had been abstinent for more than
a month and who were compared with healthy controls. The sample of the
third studied included 40 alcohol dependent men, who proceeded from
study 2, and who were assessed with laboratory impulsivity paradigms
after having been tested on SR and PPI. Our studies have found that
alcohol dependent patients exhibit a reduced magnitude of the SR and
impairments in the PPI compared to healthy controls. Impairments in the
PPI are even more evident when the subject is actively consuming alcohol
and during early detoxification, and tend to partially improve after
the detoxification process is successfully completed, although
percentages of PPI do not reach the levels of healthy controls. Finally,
we found that variables of the SR and variables of impulsivity were
correlated in abstinent alcohol dependent patients, but not in controls.
In conclusion, SR and PPI could be useful tools for the assessment of
patients with alcohol dependence. They could either be considered as
vulnerability markers for the development of alcohol or be an index of
alcohol neurotoxicity in the central nervous system.


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Last updated on 2019-13-08 at 00:45