Sensory Gating Deficits in First-Episode Psychosis

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Publication Details

Subtitle: Evidence From Neurophysiology, Psychophysiology, and Neuropsychology
Author list: Jurado Barba R
Publisher: Lippincott, Williams & Wilkins
Publication year: 2016
Journal: Journal of Nervous and Mental Disease (0022-3018)
Volume number: 204
Issue number: 12
Start page: 877
End page: 884
Number of pages: 8
ISSN: 0022-3018
Languages: English-Great Britain (EN-GB)


Abstract

Sensory gating deficits are commonly found in patients with
schizophrenia. However, there is still scarce research on this issue.
Thirty-eight patients with first-episode psychosis (FEP) were compared
to thirty-eight controls. A condition-test paradigm of event-related
potentials (ERP), prepulse inhibition (PPI), and some specific tasks of
the MATRICS Consensus Cognitive Battery (MCCB) were used (i.e., TMT,
BACS-SC, and Fluency for processing speed and CPT-IP for attention and
vigilance). The ERP components measured were P50, N1, and P2. The PPI
intervals examined were 30, 60, and 120 msec. Regarding the MCCB,
processing speed and attention/vigilance cognitive domains were
selected. FEP patients showed significant deficits in N1 and P2
components, at 30 and 60 PPI levels and in all the MCCB subtests
selected. We obtained significant relationships in N1 with PPI-60, and
with one MCCB subtest for processing speed. In addition, this same
subtest showed significant association with P2. Therefore, sensory
gating functioning is widely impaired since the very early stages of
schizophrenia.


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Last updated on 2019-13-08 at 00:45