Elevated midline-parietal gamma band noise power in schizophrenia but not in bipolar patients

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Publication Details

Author list: Jurado Barba R
Publisher: Springer (part of Springer Nature): Springer Open Choice Hybrid Journals
Publication year: 2016
Journal: European Archives of Psychiatry and Clinical Neuroscience (0940-1334)
Volume number: 266
Issue number: 8
Start page: 743
End page: 753
Number of pages: 11
ISSN: 0940-1334
eISSN: 1433-8491
Languages: English-Great Britain (EN-GB)


Abstract

Gamma oscillations are key in coordinating brain activity and seem to be
altered in schizophrenia. In previous work, we studied the spatial
distribution of a noise power measure (scalp-recorded
electroencephalographic activity unlocked to stimuli) and found higher
magnitudes in the gamma band related to symptoms and cognition in
schizophrenia. In the current study, we sought to replicate those
findings and to study its specificity for schizophrenia in a completely
independent sample. A principal component analysis (PCA) was used to
determine the factorial structure of gamma noise power acquired with an
electroencephalographic recording during an odd-ball P300 paradigm in
the 250- to 550-ms window in 70 patients with schizophrenia (16 patients
with first episode), 45 bipolar patients and 65 healthy controls.
Clinical and cognitive correlates of the resulting factors were also
assessed. Three factors arose from the PCA. The first displayed a
midline-parietal distribution (roughly corresponding to the default mode
network), the second was centro-temporal and the third
anterior-frontal. Schizophrenia but not bipolar patients showed higher
gamma noise power loadings in the first factor in comparison with
controls. Scores for this factor were significantly and directly
associated with positive and total symptoms in patients and inversely
associated with global cognition in all participants. The results of
this study replicate those of our previous publication and suggest an
elevated midline-parietal gamma noise power specific to schizophrenia.
The gamma noise power measure seems to be a useful tool for studying
background oscillatory activity during performance of cognitive tasks.


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Last updated on 2019-10-08 at 00:30