Characterizing cannabis-induced psychosis

Journal article


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Publication Details

Subtitle: a study with prepulse inhibition of the startle reflex
Author list: Jurado Barba R
Publisher: Elsevier: 12 months
Publication year: 2014
Journal: Psychiatry Research (0165-1781)
Volume number: 220
Issue number: 1-2
Start page: 535
End page: 540
Number of pages: 6
ISSN: 0165-1781
Languages: English-Great Britain (EN-GB)


Cannabis-induced psychotic disorder (CIPD) refers to psychotic symptoms
that arise in the context of cannabis intoxication. Prepulse inhibition
(PPI) deficits have been extensively identified in schizophrenia and in
cannabis abusers. We aimed to characterize PPI in CIPD patients. We used
a sample of 48 CIPD patients, 54 schizophrenia patients and cannabis
abuse (SCHZ), 44 cannabis dependents (CD), and 44 controls. CIPD, SCHZ
and CD were abstinent of cannabis consumption for 9 months. Participants
were assessed with PPI at 30, 60, and 120 ms. At 30 ms, CIPD showed
lower PPI levels than controls, and SCHZ obtained worse functioning than
controls and CD. At 60 ms, only SCHZ exhibited worse PPI percentages
(of object) than controls. Finally, at 120 ms, CIPD showed higher PPI
levels than SCHZ, and SCHZ obtained lower percentages than controls. We
found that CIPD and SCHZ patients showed deficits at the most
pre-attentional levels, whereas CIPD patients performed better than SCHZ
at higher attentional levels. These results suggest that CIPD
constitutes a different group of patients than that of SCHZ. Deficits in
PPI functioning at 30 ms could be a useful psychophysiological measure
to detect CIPD patients, who are frequently confused with cannabis
abusers whose symptoms may mimic that of schizophrenia.


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Last updated on 2019-13-08 at 00:45