Cannabis abuse effects on prepulse inhibition in patients with first episode psychosis in schizophrenia.

Journal article


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Publication Details

Author list: Jurado Barba R
Publisher: American Psychiatric Publishing
Publication year: 2015
Journal: Journal of Neuropsychiatry and Clinical Neurosciences (0895-0172)
Volume number: 27
Issue number: 1
Start page: 48
End page: 53
Number of pages: 6
ISSN: 0895-0172
eISSN: 1545-7222
Languages: English-Great Britain (EN-GB)


Deficits in prepulse inhibition (PPI) and cannabis abuse are
consistently found in schizophrenia. The authors studied PPI deficits in
first episode psychosis (FEP) with schizophrenia and cannabis abuse
influence. Thirty-five patients with FEP and 22 control subjects were
examined. Patients were divided into cannabis use disorder (CUD) (N=21)
and non-CUD (N=14). Startle measures were as follows: PPI at 30, 60, and
120 msec. Patients with CUD and patients without CUD showed lower PPI
at 30 msec than control subjects. At 60 msec, patients with CUD obtained
higher %PPI than patients without CUD, and patients without CUD
obtained lower levels than control subjects. These findings show that
cannabis abuse may improve PPI in patients with FEP at some levels.


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Last updated on 2019-13-08 at 00:45