Induced oscillatory responses during the Sternberg's visual memory task in patients with Alzheimer's disease and mild cognitive impairment




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Details zur Publikation

Autorenliste: Canuet L
Verlag: Elsevier
Jahr der Veröffentlichung: 2012
Zeitschrift: NeuroImage (1053-8119)
Bandnummer: 59
Heftnummer: 4
Erste Seite: 4132
Letzte Seite: 4140
Seitenumfang: 9
ISSN: 1053-8119
Sprachen: Englisch-Vereinigtes Königreich (EN-GB)


In this study we used magnetoencephalography during a modified version
of the Sternberg's memory recognition task performed by patients with
early Alzheimer's disease (AD), mild cognitive impairment (MCI), and by
age-matched healthy controls to identify differences in induced
oscillatory responses. For analyses, we focused on the retention period
of the working memory task. Multiple-source beamformer and Brain Voyager
were used for localization of source-power changes across the cortex
and for statistic group analyses, respectively. We found significant
differences in oscillatory response during the task, specifically in
beta and gamma frequency bands: patients with AD showed reduced beta
event-related desynchronization (ERD) in the right central area compared
to controls, and reduced gamma ERD in the left prefrontal and medial
parietal cortex compared to patients with MCI. Our findings suggest that
reduced oscillatory responses over certain brain regions in high
frequency bands (i.e., beta, gamma), and especially in the beta band
that was significantly different between AD patients and healthy
subjects, may represent brain electromagnetic changes underlying
visual-object working memory dysfunction in early AD, and a
neurophysiological indicator of cognitive decline.


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