Impaired regional hemodynamic response in schizophrenia during multiple prefrontal activation tasks




Es wurden keine entsprechenden Inhalte gefunden.

Details zur Publikation

Untertitel: a two-channel near-infrared spectroscopy study
Autorenliste: Canuet L
Verlag: Elsevier: 12 months
Jahr der Veröffentlichung: 2009
Zeitschrift: Schizophrenia Research (0920-9964)
Bandnummer: 108
Heftnummer: 1-3
Erste Seite: 93
Letzte Seite: 103
Seitenumfang: 11
ISSN: 0920-9964
Sprachen: Englisch-Vereinigtes Königreich (EN-GB)


In schizophrenia, dysfunction of the prefrontal cortex (PFC), regarded
as a core feature of the disease, has been investigated by different
neuroimaging methods. Near infrared spectroscopy (NIRS), a novel
neurophysiological method, is being increasingly used in the
investigation of frontal dysfunction in schizophrenia. However, NIRS
measurements during multiple frontal activation tasks have been rarely
reported. The purpose of this study was to compare hemodynamic changes
in the PFC between patients with schizophrenia and healthy controls
during four different types of frontal lobe tasks using a 2-channel NIRS
system. Thirty patients with schizophrenia and thirty age- and
gender-matched healthy controls were enrolled in this study. In both
groups, changes in oxygenated hemoglobin concentration (Delta[oxyHb]) at
the bilateral forehead were measured during Verbal fluency test letter
version (VFT-letter), VFT category version, Tower of Hanoi (TOH), the
Sternberg and Stroop tasks. Regarding Delta[oxyHb] in PFC, a diagnosis
group effect was found for VFT-letter and TOH. Significant negative
correlation was found between left Delta[oxyHb] during TOH and negative
and cognitive symptom scores in schizophrenia patients. Right
Delta[oxyHb] during TOH also showed significant negative correlation
with cognitive symptoms scores. No significant correlation between
Delta[oxyHb] and clinical characteristics were observed during
VFT-letter. These findings suggest that among a battery of frontal lobe
tasks administered to schizophrenia patients, VFT-letter and TOH are
more sensitive to detect PFC activation, as indicated by Delta[oxyHb]
using a 2-channel NIRS. Taken together, these findings and those of
previous neuroimaging studies suggest that VFT-letter and TOH might
represent possible candidate physiological markers of prefrontal
dysfunction in schizophrenia, though extensive testing in clinical
settings will be necessary.


Es wurden keine entsprechenden Inhalte gefunden.


Es wurden keine entsprechenden Inhalte gefunden.

Zuletzt aktualisiert 2019-13-08 um 00:45