Impaired prepulse inhibition and habituation of acoustic startle response in Japanese patients with schizophrenia




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Details zur Publikation

Autorenliste: Canuet L
Verlag: Elsevier: 12 months
Jahr der Veröffentlichung: 2008
Zeitschrift: Neuroscience Research (0168-0102)
Bandnummer: 62
Heftnummer: 3
Erste Seite: 187
Letzte Seite: 194
Seitenumfang: 8
ISSN: 0168-0102
Sprachen: Englisch-Vereinigtes Königreich (EN-GB)


Prepulse inhibition (PPI) and habituation of the acoustic startle reflex
(ASR) are considered to be candidate endophenotypes of schizophrenia.
However, to our knowledge, only one group has investigated these startle
measures in Asian patients with schizophrenia. In the present study, we
evaluated these startle measures in 51 Japanese patients with
schizophrenia and compared them with those of 55 healthy age- and
sex-matched Japanese controls. A human startle response monitoring
system was used to deliver acoustic startle stimuli, and record and
score the electromyographic activity of the orbicularis oculi muscle.
The startle measures examined were mean magnitude of ASR to pulse alone
trials in initial block (SR), habituation of ASR during the session
(HAB), and PPI at prepulse intensities of 82 dB (PPI82), 86 dB (PPI86),
and 90 dB (PPI90) sound pressure level. SR was not significantly
different between the patients and controls. Patients displayed
significantly reduced HAB and PPI for all prepulse intensities compared
to controls. The greatest statistical difference in PPI between patients
and controls was found with PPI86. This did not correlate with any
clinical variable in each group. Our results indicate that PPI and
habituation of ASR are impaired in Asian patients with schizophrenia.


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