Randomised clinical trial comparing oral versus depot formulations of zuclopenthixol in patients with schizophrenia and previous violence




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Details zur Publikation

Autorenliste: Bombin I
Verlag: Elsevier Masson / Elsevier: 12 months
Jahr der Veröffentlichung: 2006
Bandnummer: 21
Heftnummer: 1
Erste Seite: 34
Letzte Seite: 40
Seitenumfang: 7
ISSN: 0924-9338
Sprachen: Englisch-Vereinigtes Königreich (EN-GB)


Purpose. - The aim of this longitudinal study was to determine whether
the depot formulation of an antipsychotic reduces violence in
outpatients with schizophrenia as compared to oral administration of the
same antipsychotic. Methods. - Forty-six previously violent patients
with schizophrenia were randomised to receive treatment with oral or
depot zuclopenthixol for 1:year. Clinicians interviewed patients at
baseline and every month thereafter to assess treatment adherence. An
interviewer blinded to treatment assignments interviewed an informant
about any violent behaviour during the previous month. Results. -
Violence during the follow-up year was inversely proportional to
treatment adherence, better compliance, and greater reduction of
positive symptoms. Lower frequency of violent acts was observed in the
depot group. The level of insight at baseline was not significantly
associated with violence recidivism. Regardless of route of
administration, treatment non-adherence was the best predictor of
violence. Conclusions. - Some patients with schizophrenia and prior
violent behaviour may benefit from the depot formulation of
antipsychotic medication.


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Zuletzt aktualisiert 2019-13-08 um 00:45