Quantitative magnetoencephalography of spontaneous brain activity in Alzheimer disease

Journal article


Research Areas

No matching items found.

Publication Details

Subtitle: An exhaustive frequency analysis
Author list: Maestu F
Publisher: Lippincott, Williams & Wilkins
Publication year: 2006
Volume number: 20
Issue number: 3
Start page: 153
End page: 159
Number of pages: 7
ISSN: 0893-0341
Languages: English-Great Britain (EN-GB)


Quantitative magnetoencephalography (qMEG) was used to investigate
differences in the 2 to 60 Hz spectral power, between Alzheimer disease
(AD) patients and control subjects. Twenty-two AD patients and 21
age-matched control subjects participated in this study. MEG signal
analysis comprised the division of the entire 2 to 60 Hz spectrum in 2
Hz-width subbands. Both the relative power and the contribution of each
subband to the correct classification of AD patients and controls were
calculated. The relative power in 2 bands comprised between 2 to 4 Hz
and 16 to 28 Hz was selected by a restrictive multiple-comparison test..
among the entire 2 to 60 Hz spectrum. Using 2 to 4 Hz values it is
possible to choose a classification rule with an estimate sensitivity
and specificity given by 68% and 76% respectively. Alternatively.. when
16 to 28 Hz values are used, it is possible to obtain a better
classification rule with an estimate sensitivity and specificity given
by 81% and 80%, respectively. To the best of our knowledge.. this is the
first electroencephalography or MEG study where a so exhaustive
analysis of the magnetoelectric spectrum has been performed. This study
supports the notion that more attention should be devoted to the study
of beta band in AD.


No matching items found.


No matching items found.

Last updated on 2019-13-08 at 00:45