Neurophysiology and cognitive deterioration in epilepsy

Journal article


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Publication Details

Author list: Maestu F
Publisher: Cesar Viguera
Publication year: 1999
Journal: Revista de Neurologia (0210-0010)
Volume number: 28
Issue number: 8
Start page: 793
End page: 798
Number of pages: 6
ISSN: 0210-0010
Languages: English-Great Britain (EN-GB)


Objective. To carry out a critical evaluation of the international
literature on the neuropsychology of epilepsy. The variables which lead
to cognitive deterioration in epilepsy and the effect on cognition of
different treatments available (pharmacological and surgical).
Development. We evaluate the influence of different neurological
variables on the higher functions (aetiology, age of onset, type of
crises, duration of illness, frequency and anti-epileptic drugs). We
also describe the cognitive functions most affected in epilepsy (memory,
attention, executive function, language). Studies of the surgery of
epilepsy show that this may lead to both beneficial and undesirable
effects on cognition. Conclusions. The variables which in general most
affect higher functions are the duration of the illness and the
frequency and types of crises. The commonest neuropsychological effects
are those of memory deficit. These studies show that neuropsychological
studies should be done front the time of onset of the disorder. Finally,
from the surgical point of view, young patients with considerable cr
isis reduction or free of crises, with moderate preoperative
deterioration of memory have the greatest possibility of post-operative
improvement in cognition. Older persons with intact cognitive function
and major surgical resection have more possibilities of post-surgical


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Last updated on 2019-10-08 at 00:15