Magnetoencephalographic localization of peritumoral temporal epileptic focus previous surgical resection

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Publication Details

Author list: Maestu F
Publisher: Elsevier: 12 months
Publication year: 2003
Volume number: 12
Issue number: 1
Start page: 19
End page: 22
Number of pages: 4
ISSN: 1059-1311
Languages: English-Great Britain (EN-GB)


Magnetoencephalography (MEG) is suggested as a localizing technique of
epileptogenic areas in drug-resistant seizure patients due to
intracraneal lesions. A male 42-year-old patient who begins at 26 with
partial complex drug-resistant seizures is put forward. MRI shows a 9 mm
diameter lesion located in left superior temporal gyrus which seems
compatible with cavernoma. Both conventional and sleep deprivation EEGs
have proved normal. Sleep EEG shows sharp waves in left temporal region.
MEG helps to localize interictal spike and spike-wave activity, as well
as wide slow wave (2-7 Hz) activity areas. Cramotomy under analgesia
and aware sedation conditions is carried out. Intrasurgery cortical
electric stimulation assisted by neuronavigator causes a limited partial
complex seizure which the patient recognizes to be exactly like his.
Thus, MEG localization of the epileptogenic area is confirmed. Surgical
resection of both the lesion and the epileptogenic area is carried out.
The patient remains free from seizures 9 months after surgery. A control
MEG study reveals no epileptogenic nor slow wave activity. Conclusion:
in this particular case, MEG has proven to be a useful presurgical
evaluation technique to localize epileptogenic activity, validated by
intrasurgical cortical stimulation.


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Last updated on 2019-13-08 at 00:45