Is medial temporal lobe activation specific for encoding long-term memories?




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Details zur Publikation

Autorenliste: Maestu F
Verlag: Elsevier
Jahr der Veröffentlichung: 2005
Bandnummer: 25
Heftnummer: 1
Erste Seite: 34
Letzte Seite: 42
Seitenumfang: 9
ISSN: 1053-8119
Sprachen: Englisch-Vereinigtes Königreich (EN-GB)


Several neuroimaging studies have consistently demonstrated the critical
involvement of prefrontal cortices and medial temporal lobes during
long-term encoding. While the contribution of prefrontal lobes to
working memory is well established, the role of the MTL structures
remains controversial. To address this issue, we registered the
neuro-magnetic brain patterns of eight adult volunteers while they
performed two working memory tasks (verbal and spatial) using
magnetoencephalography (MEG). MEG recordings can provide real-time
measures of brain activity, thus allowing detailed tracking of the
time-course of brain activation during the encoding phase. We detected
sustained and material-specific activity on the MTLs during the encoding
phase of a working memory task, based on verbal and spatial
information. Two peaks of activation were noted in the left MTL during
word encoding in two non-consecutive time periods (500-600 ms and
700-800 ms after stimulus onset). Right MTL laterality was found for
encoding locations when we collapsed activity sources in a wider time
period (400-800 ms). In addition, we provided the spatiotemporal
profiles of what seems to be two different brain circuits specific for
each type of material. Finally, following an emerging conceptualization
of working memory, we hypothesized that encoding processes mediated by
the MTL to long-term memory would also apply to working memory.


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