Increased occipital delta dipole density in major depressive disorder determined by magnetoencephalography




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Details zur Publikation

Autorenliste: Maestu F
Verlag: Canadian Medical Association
Jahr der Veröffentlichung: 2005
Bandnummer: 30
Heftnummer: 1
Erste Seite: 17
Letzte Seite: 23
Seitenumfang: 7
ISSN: 1180-4882
Sprachen: Englisch-Vereinigtes Königreich (EN-GB)


Objective: To test the hypothesis that there is increased low-frequency
activity located predominantly in the frontal lobe in patients with
major depressive disorder using magnetoencephalography. Methods: We
carried out an unmatched or separate sampling case-control study of 31
medication-free patients who met the Diagnostic and Statistical Manual
of Mental Disorders, fourth edition (DSM-IV), criteria for major
depressive disorder and were outpatients of the Hospital Central de la
Defensa, Madrid, and 22 healthy control subjects with no history of
mental illness. A logistic regression analysis was employed to examine
the predictive value of magnetoencephalography dipole density scores in
the diagnosis of depression. We attempted to locate generators of focal
magnetic slow waves by employing a single moving dipole model and by
calculating dipole densities in prefrontal, frontal, parietal, temporal
and occipital areas. The study lasted from February 2001 to January
2003. Results: Only 2 dipole density scores, right occipital delta and
left temporal delta, were significantly related to depression. According
to the comparison of univariate and multivariate models and odds
ratios, the right occipital delta dipole density is the factor with the
greatest predictive power for depression, and the only one to show a
significant correlation with severity of depression. Conclusions: We did
not find any frontal lobe functional alteration. Our study provides, to
the best of our knowledge, the first evidence of abnormal focal
magnetic low-frequency activity in the occipital lobe of untreated
patients with depression. Increased occipital lobe delta dipole density
seems to be a reliable risk factor for depression, which correlates with
disease severity according to the Hamilton Rating Scale for Depression.


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Zuletzt aktualisiert 2019-10-08 um 00:15