Increased biomagnetic activity in the ventral pathway in mild cognitive impairment

Zeitschriftenaufsatz


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Details zur Publikation

Autorenliste: Maestu F
Verlag: Elsevier: 12 months
Jahr der Veröffentlichung: 2008
Bandnummer: 119
Heftnummer: 6
Erste Seite: 1320
Letzte Seite: 1327
Seitenumfang: 8
ISSN: 1388-2457
Sprachen: Englisch-Vereinigtes Königreich (EN-GB)


Beschreibung

Objective: Mild cognitive impairment (MCI) patients represent an
intermediary state between healthy aging and dementia. MCI activation
profiles, recorded during a memory task, have been studied either
through high spatial resolution or high temporal resolution techniques.
However, little is known about the benefit of combining both dimensions.
Here, we investigate, by means of magnetoencephalography (MEG), whether
spatio-temporal profiles of neuromagnetic activity could differentiate
between MCI and age-matched elderly participants.



Methods: Taking the advantage of the high temporal resolution and
good spatial resolution of MEG, neuromagnetic activity from 15 elderly
MCI patients and 20 age-matched controls was recorded during the
performance of a modified version of the Sternberg paradigm.



Results: Behavioral performance was similar in both groups. A
between group analysis revealed that MCI patients showed bilateral
higher activity in the ventral pathway, in both the target and the
non-target stimuli. A within-group analysis of the target stimuli,
indicates a lack of asymmetry through all late latency windows in both
groups.



Conclusions: MCI patients showed a compensatory mechanism
represented by an increased bilateral activity of the ventral pathway in
order to achieve a behavioral performance similar to the control group.



Significance: This spatio-temporal pattern of activity could be
another tool to differentiate between healthy aging and MCI patients.


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Zuletzt aktualisiert 2019-13-08 um 00:45