Increased biomagnetic activity in healthy elderly with subjective memory complaints

Zeitschriftenaufsatz


Autoren/Herausgeber


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Details zur Publikation

Autorenliste: Maestu F
Verlag: Elsevier: 12 months
Jahr der Veröffentlichung: 2011
Bandnummer: 122
Heftnummer: 3
Erste Seite: 499
Letzte Seite: 505
Seitenumfang: 7
ISSN: 1388-2457
Sprachen: Englisch-Vereinigtes Königreich (EN-GB)


Beschreibung

Objective: Subjective memory complaints (SMCs) are frequently reported
by elderly people with or without objective cognitive impairment (OMI)
as assessed by neuropsychological tests. We investigate whether SMCs are
associated with altered brain biomagnetic patterns even in the absence
of OMI.



Methods: We report spatio-temporal patterns of brain magnetic
activity recorded with magnetoencephalography during a memory task in 51
elderly participants divided into the following groups: patients with
mild cognitive impairment (MCI) with SMC and OMI, individuals with SMC
but not OMI, and healthy controls without neither SMC nor OMI. Exclusion
criteria for all three groups included a diagnosis of depression or any
other psychiatric condition.



Results: No statistically significant differences were found between
MCI patients and participants with SMC. However, the SMC showed higher
activation, between 200 and 900 ms after stimulus onset, than the
control group in posterior ventral regions and in the dorsal pathway.
MCI patients showed higher activation than the control group in the
posterior part of the ventral pathway.



Conclusions: These findings suggest that similar physiological
mechanisms may underlie SMC and MCI, which could be two stages in a
cognitive continuum.



Significance: MEG provide different neurophysiological profiles between SMC and control subjects.


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Zuletzt aktualisiert 2019-13-08 um 00:45