Task-induced deactivation from rest extends beyond the default mode brain network

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Liste des auteurs: Soriano-Mas C
Editeur: Public Library of Science
Année de publication: 2011
Journal: PLoS ONE (1932-6203)
Numéro du volume: 6
Numéro de publication: 7
Page d'accueil: e22964
Nombre de pages: 9
ISSN: 1932-6203
eISSN: 1932-6203
Languages: Anglais-Royaume-Uni (EN-GB)


Résumé

Activity decreases, or deactivations, of midline and parietal cortical
brain regions are routinely observed in human functional neuroimaging
studies that compare periods of task-based cognitive performance with
passive states, such as rest. It is now widely held that such
task-induced deactivations index a highly organized 'default-mode
network' (DMN): a large-scale brain system whose discovery has had broad
implications in the study of human brain function and behavior. In this
work, we show that common task-induced deactivations from rest also
occur outside of the DMN as a function of increased task demand. Fifty
healthy adult subjects performed two distinct functional magnetic
resonance imaging tasks that were designed to reliably map deactivations
from a resting baseline. As primary findings, increases in task demand
consistently modulated the regional anatomy of DMN deactivation. At high
levels of task demand, robust deactivation was observed in non-DMN
regions, most notably, the posterior insular cortex. Deactivation of
this region was directly implicated in a performance-based analysis of
experienced task difficulty. Together, these findings suggest that
task-induced deactivations from rest are not limited to the DMN and
extend to brain regions typically associated with integrative sensory
and interoceptive processes.


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