Neural substrates of cognitive flexibility in cocaine and gambling addictions

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Publication Details

Author list: Soriano-Mas C
Publisher: Cambridge University Press (CUP): STM Journals
Publication year: 2015
Journal: British Journal of Psychiatry (0007-1250)
Volume number: 207
Issue number: 2
Start page: 158
End page: 164
Number of pages: 7
ISSN: 0007-1250
eISSN: 1472-1465
Languages: English-Great Britain (EN-GB)


Individuals with cocaine and gambling addictions exhibit cognitive
flexibility deficits that may underlie persistence of harmful
behaviours.We investigated the neural substrates of cognitive
inflexibility in cocaine users v. pathological gamblers, aiming to
disambiguate common mechanisms v. cocaine effects.Eighteen cocaine
users, 18 pathological gamblers and 18 controls performed a
probabilistic reversal learning task during functional magnetic
resonance imaging, and were genotyped for the DRD2/ANKK Taq1A
polymorphism.Cocaine users and pathological gamblers exhibited reduced
ventrolateral prefrontal cortex (PFC) signal during reversal shifting.
Cocaine users further showed increased dorsomedial PFC (dmPFC)
activation relative to pathological gamblers during perseveration, and
decreased dorsolateral PFC activation relative to pathological gamblers
and controls during shifting. Preliminary genetic findings indicated
that cocaine users carrying the DRD2/ANKK Taq1A1+ genotype may derive
unique stimulatory effects on shifting-related ventrolateral PFC
signal.Reduced ventrolateral PFC activation during shifting may
constitute a common neural marker across gambling and cocaine
addictions. Additional cocaine-related effects relate to a wider pattern
of task-related dysregulation, reflected in signal abnormalities in
dorsolateral and dmPFC.


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Last updated on 2019-13-08 at 00:45