Neural correlates of obsessive-compulsive related dysfunctional beliefs

Journal article


Authors/Editors


Research Areas

No matching items found.


Publication Details

Author list: Soriano-Mas C
Publisher: Elsevier: 12 months
Publication year: 2013
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry (0278-5846)
Volume number: 47
Start page: 25
End page: 32
Number of pages: 8
ISSN: 0278-5846
Languages: English-Great Britain (EN-GB)


Abstract

There have been few attempts to integrate neurobiological and cognitive
models of obsessive-compulsive disorder (OCD), although this might
constitute a key approach to clarify the complex etiology of the
disorder. Our study aimed to explore the neural correlates underlying
dysfunctional beliefs hypothesized by cognitive models to be involved in
the development and maintenance of OCD. We obtained a high-resolution
magnetic resonance image from fifty OCD patients and 30 healthy
controls, and correlated them, voxel-wise, with the severity of
OC-related dysfunctional beliefs assessed by the Obsessive Beliefs
Questionnaire-44. In healthy controls, significant negative correlations
were observed between anterior temporal lobe (ATL) volume and scores on
perfectionism/intolerance of uncertainty and overimportance/need to
control thoughts. No significant correlations between OBQ-44 domains and
regional gray matter volumes were observed in OCD patients. A post-hoc
region-of-interest analysis detected that the ATLs was bilaterally
smaller in OCD patients. On splitting subjects into high- and low-belief
subgroups, we observed that such brain structural differences between
OCD patients and healthy controls were explained by significantly larger
ATL volumes among healthy subjects from the low-belief subgroup. Our
results suggest a significant correlation between OC-related
dysfunctional beliefs and morphometric variability in the anterior
temporal lobe, a brain structure related to socio-emotional processing.
Future studies should address the interaction of these correlations with
environmental factors to fully characterize the bases of OC-related
dysfunctional beliefs and to advance in the integration of biological
and cognitive models of OCD.


Keywords

No matching items found.


Documents

No matching items found.

Last updated on 2019-13-08 at 00:45