Neural correlates of minor hallucinations in non-demented patients with Parkinson's disease

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Publication Details

Author list: Soriano-Mas C
Publisher: Elsevier
Publication year: 2014
Journal: Parkinsonism and Related Disorders (1353-8020)
Volume number: 20
Issue number: 3
Start page: 290
End page: 296
Number of pages: 7
ISSN: 1353-8020
Languages: English-Great Britain (EN-GB)


Abstract

BACKGROUND: Hallucinations are a frequent and severe complication in
Parkinson's disease (PD). Minor hallucinations are generally not
disturbing, but likely progress to well-structured hallucinations with
loss of insight and a great impact on quality of life. Knowledge on the
neural bases of minor hallucinations may help to describe those systems
associated with the early development of psychotic phenomena in PD. In
this study, we aimed to identify the pattern of structural brain
alterations associated with minor hallucinations in PD by using
voxel-based morphometry (VBM). METHODS: We prospectively collected a
sample of 46 non-demented PD patients, with (N = 17) and without (n =
29) minor hallucinations (passage and/or presence hallucinations), and
15 healthy controls. Groups were matched for age, education and global
cognitive function. Presence and type of minor psychotic phenomena was
assessed by the new MDS-UPDRS. Three dimensional T1-weighted MRI images
were acquired with a 1.5 T magnet, and analyzed using optimized VBM.
RESULTS: Compared to controls, PD with minor hallucinations (PD-mH)
showed reduced gray matter volume bilaterally in different areas of the
dorsal visual stream, and in functionally related midbrain and
cerebellar structures. Additionally, bilateral gray matter volume
increases were observed in the PD-mH group in limbic and paralimbic
regions. CONCLUSIONS: Our data support a major role of the dorsal visual
stream in the genesis of minor hallucinations in PD, reinforcing the
importance of posterior cortical regions for the development of
cognitive and psychiatric complications in PD.


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Last updated on 2019-13-08 at 00:45