Negative urgency, disinhibition and reduced temporal pole gray matter characterize the comorbidity of cocaine dependence and personality disorders

Journal article


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Publication Details

Author list: Soriano-Mas C
Publisher: Elsevier: 12 months
Publication year: 2013
Journal: Drug and Alcohol Dependence (0376-8716)
Volume number: 132
Issue number: 1-2
Start page: 231
End page: 237
Number of pages: 7
ISSN: 0376-8716
Languages: English-Great Britain (EN-GB)


BACKGROUND: Individuals with cocaine dependence and co-occurring
personality disorders are more likely to have increased impulsivity,
dysfunctional beliefs, executive dysfunction and brain structural
abnormalities by virtue of the conjoint impact of both pathologies.
METHODS: We recruited 32 cocaine dependent patients with comorbid
Cluster B personality disorders, 44 cocaine dependent patients without
comorbidities and 34 non-drug-using controls. They completed the UPPS-P
impulsivity scale, the Personality Belief Questionnaire, and executive
function tests of working memory, attention/response inhibition and
shifting. A subsample (n=61) was also scanned using Magnetic Resonance
Imaging. We used univariate ANOVAs for group comparisons, and tested the
association between impulsivity, executive control and personality
dysfunction and diagnoses using correlation and multivariate logistic
regression analyses. RESULTS: Cocaine dependent patients with
personality disorders had elevated negative urgency and borderline
beliefs, decreased inhibition and attention regulation, and reduced
temporal pole gray matter with respect to the rest of the sample. Trait
and cognitive measures correctly classified 73% of comorbid patients
(60% sensitivity and 82% specificity). CONCLUSION: The co-occurrence of
cocaine dependence and personality disorders is associated with
negative-mood impulsivity and beliefs, executive dysfunction and
temporal pole attrition.


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Last updated on 2019-13-08 at 00:45