Naproxen effects on brain response to painful pressure stimulation in patients with knee osteoarthritis

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Publication Details

Subtitle: a double-blind, randomized, placebo-controlled, single-dose study
Author list: Soriano-Mas C
Publisher: Journal of Rheumatology
Publication year: 2014
Journal: Journal of Rheumatology (0315-162X)
Volume number: 41
Issue number: 11
Start page: 2240
End page: 2248
Number of pages: 9
ISSN: 0315-162X
eISSN: 1499-2752
Languages: English-Great Britain (EN-GB)


The aim of our study was to investigate the effects of naproxen, an
antiinflammatory analgesic drug, on brain response to painful
stimulation on the affected knee in chronic osteoarthritis (OA) using
functional magnetic resonance imaging (fMRI) in a double-blind,
placebo-controlled study.A sample of 25 patients with knee OA received
naproxen (500 mg), placebo, or no treatment in 3 separate sessions in a
randomized manner. Pressure stimulation was applied to the medial
articular interline of the knee during the fMRI pain sequence. We
evaluated subjective pain ratings at every session and their association
with brain responses to pain. An fMRI control paradigm was included to
discard global brain vascular effects of naproxen.We found brain
activation reductions under naproxen compared to no treatment in
different cortical and subcortical core pain processing regions
(p≤0.001). Compared to placebo, naproxen triggered an attenuation of
amygdala activation (p=0.001). Placebo extended its attenuation effects
beyond the classical pain processing network (p≤0.001). Subjective pain
scores during the fMRI painful task differed between naproxen and no
treatment (p=0.037). Activation attenuation under naproxen in different
regions (i.e., ventral brain, cingulate gyrus) was accompanied by an
improvement in the subjective pain complaints (p≤0.002).Naproxen
effectively reduces pain-related brain responses involving different
regions and the attenuation is related to subjective pain changes. Our
current work yields further support to the utility of fMRI to objectify
the acute analgesic effects of a single naproxen dose in patients
affected by knee OA. The trial was registered at the
EuropeanClinicalTrials Database, "EudraCT Number 2008-004501-33".


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Last updated on 2019-13-08 at 00:45