Intracranial self-stimulation facilitates memory consolidation, but not retrieval

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Details zur Publikation

Untertitel: its effects are more effective than increased training
Autorenliste: Soriano-Mas C
Verlag: Elsevier
Jahr der Veröffentlichung: 2002
Zeitschrift: Behavioural Brain Research (0166-4328)
Bandnummer: 129
Heftnummer: 1-2
Erste Seite: 65
Letzte Seite: 75
Seitenumfang: 11
ISSN: 0166-4328
Sprachen: Englisch-Vereinigtes Königreich (EN-GB)


Beschreibung

To evaluate possible differential effects of lateral hypothalamic
intracranial self-stimulation (ICSS) on memory consolidation and
retrieval, independent groups of Wistar rats were trained in a single
session of two-way active avoidance task (acquisition session) and
tested 24 h later (retention session). The post-ICSS groups received an
ICSS treatment immediately after the acquisition session, and the
pre-ICSS groups received the same treatment immediately before the
retention session. Because the ICSS effects on memory seem to be
dependent on the initial performance level shown by the subjects, the
possible influence of initial training (number of trials) on ICSS
effects was also studied. Therefore, we used different control and
experimental groups, which received either 30 or 50 trials in the
acquisition session. Post-training ICSS facilitated the 24-h retention
in both training conditions (30 and 50 trials). In contrast,
pre-retention ICSS treatment did not facilitate performance in the
retention test. We also observed that post-training ICSS was more
effective for improving the 24-h retention than increasing the initial
training from 30 to 50 trials. This findings confirm that ICSS treatment
improves memory consolidation and suggest that it might not affect
memory retrieval mechanisms.


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Zuletzt aktualisiert 2019-13-08 um 00:45