Intracranial self-stimulation after memory reactivation




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Details zur Publikation

Untertitel: immediate and late effects
Autorenliste: Soriano-Mas C
Verlag: Elsevier: 12 months
Jahr der Veröffentlichung: 2007
Zeitschrift: Brain Research Bulletin (0361-9230)
Bandnummer: 74
Heftnummer: 1-3
Erste Seite: 51
Letzte Seite: 57
Seitenumfang: 7
ISSN: 0361-9230
Sprachen: Englisch-Vereinigtes Königreich (EN-GB)


To assess whether intracranial self-stimulation (SS) given after memory
reactivation could improve memory retrieval, we tested the immediate
(Experiment 1) and late (24 h; Experiment 2) effects of an SS treatment
on the retrieval of a two-way active avoidance conditioning in Wistar
rats. Memory was reactivated 24 h after training and the reminder (Rm)
used consisted of a 3 s exposure to the conditioned stimulus (a tone) in
the same context as in the original learning. SS treatment (2500 trains
at 100% of each rat's optimal intensity) was administered immediately
afterwards. No significant differences between SS-treated and control
groups were observed when the retrieval was tested immediately after the
SS treatment with or without memory reactivation. However, retrieval
was improved when tested 24 h after SS treatment alone or after the
reminder exposure alone. The greatest improvement in avoidance was
observed when both treatments were given together, that is, when the SS
treatment was administered immediately after memory reactivation.
Moreover, there were no significant statistical interactions between the
effect of SS treatment and the ones of memory reactivation in any of
both experiments. The present results show that the effect of an
immediate SS treatment can be added to the ones of memory reactivation
causing a strong long-term facilitation of memory retrieval.


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