Influence of the fusiform gyrus on amygdala response to emotional faces in the non-clinical range of social anxiety

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Details zur Publikation

Autorenliste: Soriano-Mas C
Verlag: Cambridge University Press (CUP): STM Journals
Jahr der Veröffentlichung: 2009
Zeitschrift: Psychological Medicine (0033-2917)
Bandnummer: 39
Heftnummer: 7
Erste Seite: 1177
Letzte Seite: 1187
Seitenumfang: 11
ISSN: 0033-2917
eISSN: 1469-8978
Sprachen: Englisch-Vereinigtes Königreich (EN-GB)


Beschreibung

BACKGROUND: Social anxiety often involves a combination of
hypervigilance and avoidance to potentially warning signals including
the facial expression of emotions. Functional imaging has demonstrated
an increase in amygdala response to emotional faces in subjects with
social anxiety. Nevertheless, it is unclear to what extent visual areas
processing faces influence amygdala reactivity in different socially
anxious individuals. We assessed the influence of the fusiform gyrus
activation on amygdala response to emotional faces in the non-clinical
range of social anxiety. METHOD: Twenty-two normal subjects showing a
wide range in social anxiety scores were examined using functional
magnetic resonance imaging (fMRI) during the processing of happy and
fearful faces. A dimensional analysis approach was used involving
voxel-wise mapping of the correlation between subjects' social anxiety
scores and amygdala activation, before and after controlling for
fusiform gyrus activation. RESULTS: We observed that only after
controlling for subjects' level of activation of the fusiform gyrus was
there an association between social anxiety ratings and amygdala
response to both happy and fearful faces. The fusiform gyrus influence
was more robust during the fear condition. Of note, fusiform gyrus
response to fearful faces showed a negative correlation with additional
behavioral assessments related to avoidance, including social anxiety
scores, harm avoidance and sensitivity to punishment. CONCLUSIONS:
Relevant interactions among the emotional face-processing stages exist
in the non-clinical range of social anxiety that may ultimately
attenuate amygdala responses. Future research will help to establish the
role of this effect in a clinical context.


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Zuletzt aktualisiert 2019-13-08 um 00:45