Identifying patients with obsessive-compulsive disorder using whole-brain anatomy

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Details zur Publikation

Autorenliste: Soriano-Mas C
Verlag: Elsevier
Jahr der Veröffentlichung: 2007
Zeitschrift: NeuroImage (1053-8119)
Bandnummer: 35
Heftnummer: 3
Erste Seite: 1028
Letzte Seite: 1037
Seitenumfang: 10
ISSN: 1053-8119
Sprachen: Englisch-Vereinigtes Königreich (EN-GB)


Beschreibung

Structural neuroimaging studies have reported a variety of brain
alterations between groups of obsessive-compulsive disorder (OCD)
patients and healthy controls. However, the large heterogeneity in
discrete anatomical measures that exists among patients prevents a clear
discrimination of single patients from healthy subjects. This reduces
the potential clinical applicability of structural neuroimaging studies.
In the present study we assessed the feasibility of identifying OCD
patients on the basis of whole-brain anatomical alterations. Whole-brain
magnetic resonance images were collected from two consecutive samples
of OCD outpatients (n=72 and n=30), and control subjects (n=72 and
n=30). We computed the whole-brain (voxel-wise) pattern of structural
difference between OCD patients and control subjects at the group level.
A single expression value of this difference pattern was calculated for
each subject, expressing their degree of 'OCD-like' anatomical
alteration. Accuracy of patient classification based on these expression
values was assessed using two validation approaches. Firstly, using a
cross-validation method, we obtained a high classification accuracy
(average of the sensitivity and specificity indices) of 93.1%. In a
second assessment, which classified new groups of OCD patients and
control subjects, overall accuracy was lower at 76.6%. Individual
expression values for OCD patients were significantly correlated with
overall symptom severity as measured by the Y-BOCS scale. Our results
suggest that OCD patients can be identified on the basis of whole-brain
structural alterations, although the accuracy of our approach may be
limited by the inherent variability of psychiatric populations.
Nevertheless, the anatomical characterization of individual patients may
ultimately provide the psychiatrist with relevant biological
information.


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Zuletzt aktualisiert 2019-13-08 um 00:45