Grey matter volume differences in non-affective psychosis and the effects of age of onset on grey matter volumes

Journal article


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Publication Details

Subtitle: A voxelwise study
Author list: Soriano-Mas C
Publisher: Elsevier: 12 months
Publication year: 2015
Journal: Schizophrenia Research (0920-9964)
Volume number: 164
Issue number: 1-3
Start page: 74
End page: 82
Number of pages: 9
ISSN: 0920-9964
Languages: English-Great Britain (EN-GB)


Previous evidence indicates that structural brain alterations are
already present in the early phases of psychosis. In this study we aim
to investigate the relationships among the different diagnoses in the
spectrum of non-affective psychosis. A hundred-and-one first-episode
psychosis patients (FEP) and 69 healthy volunteers, matched for age,
gender, handedness and educational level were analyzed by structural MRI
and high-dimensional voxel-based morphometry as implemented in SPM8
software. We obtained three main results: (1) FEP patients showed
reduction of grey matter volume (GMV) in the frontal, temporal and
occipital lobes, left insula and cerebellum. (2) Age of disease onset
was an important factor revealing a gradual decrease of GMV (healthy
controls>late onset>intermediate onset>early onset) in the
frontal, temporal and occipital lobes, insula and cerebellum. (3) A
gradual reduction of GMV related to diagnosis spectrum in the frontal,
temporal, parietal and occipital lobes of schizophrenia patients being
the most affected. These results suggest that an earlier onset of
psychosis is linked to an earlier disease-related disruption of
structural brain development, which may be most pronounced in
schizophrenia compared to other psychoses.


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Last updated on 2019-13-08 at 00:45