Facilitation of a distributed shuttle-box conditioning with posttraining intracranial self-stimulation in old rats

Journal article


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Publication Details

Author list: Soriano-Mas C
Publisher: Elsevier: 12 months
Publication year: 1997
Journal: Neurobiology of Learning and Memory (1074-7427)
Volume number: 67
Issue number: 3
Start page: 254
End page: 258
Number of pages: 5
ISSN: 1074-7427
Languages: English-Great Britain (EN-GB)


Old Wistar rats (16-17 months) were trained in a two-way active
avoidance task for 5 consecutive days (10 trials/day). Immediately after
each training session a lateral hypothalamic intracranial
self-stimulation session (ICSS group) or a sham-treatment session
(Control group) was given to the animals. Long-term retention was tested
7 days after the last acquisition session. ICSS treatment led to a
significant improvement in acquisition. In the long-term retention
session the level of avoidance in both groups was similar to that
achieved in the last acquisition session, although differences among
groups failed to reach statistical significance. These results are
compared with those obtained in previous experiments with young adult
rats. While ICSS facilitated the process of acquisition in both young
and old rats (however, it was much more powerful in young animals),
further experiments are needed to elucidate whether this effect is
long-lasting in old rats, as occurs in young adult subjects.


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Last updated on 2019-13-08 at 00:45