Facilitation of a distributed shuttle-box conditioning with posttraining intracranial self-stimulation in old rats




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Details zur Publikation

Autorenliste: Soriano-Mas C
Verlag: Elsevier: 12 months
Jahr der Veröffentlichung: 1997
Zeitschrift: Neurobiology of Learning and Memory (1074-7427)
Bandnummer: 67
Heftnummer: 3
Erste Seite: 254
Letzte Seite: 258
Seitenumfang: 5
ISSN: 1074-7427
Sprachen: Englisch-Vereinigtes Königreich (EN-GB)


Old Wistar rats (16-17 months) were trained in a two-way active
avoidance task for 5 consecutive days (10 trials/day). Immediately after
each training session a lateral hypothalamic intracranial
self-stimulation session (ICSS group) or a sham-treatment session
(Control group) was given to the animals. Long-term retention was tested
7 days after the last acquisition session. ICSS treatment led to a
significant improvement in acquisition. In the long-term retention
session the level of avoidance in both groups was similar to that
achieved in the last acquisition session, although differences among
groups failed to reach statistical significance. These results are
compared with those obtained in previous experiments with young adult
rats. While ICSS facilitated the process of acquisition in both young
and old rats (however, it was much more powerful in young animals),
further experiments are needed to elucidate whether this effect is
long-lasting in old rats, as occurs in young adult subjects.


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