Impaired preparatory re-mapping of stimulus-response associations and rule-implementation in schizophrenic patients-The role for differences in early processing




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Details zur Publikation

Autorenliste: Barceló F
Verlag: Elsevier: 12 months
Jahr der Veröffentlichung: 2011
Zeitschrift: Biological Psychology (0301-0511)
Bandnummer: 87
Heftnummer: 3
Erste Seite: 358
Letzte Seite: 365
Seitenumfang: 8
ISSN: 0301-0511
Sprachen: Englisch-Vereinigtes Königreich (EN-GB)


An accurate representation of task-set information is needed for
successful goal directed behavior. Recent studies point to disturbances
in the early processing stages as plausible causes for task-switching
deficits in schizophrenia. A task-cueing protocol was administered to a
group of schizophrenic patients and compared with a sample of
age-matched healthy controls. Patients responded slower and less
accurate compared with controls in all conditions. The concurrent
recording of event-related brain potentials to contextual cues and
target events revealed abnormalities in the early processing of both
cue-locked and target-locked N1 potentials. Abnormally enhanced
target-locked P2 amplitudes were observed in schizophrenic patients for
task-switch trials only, suggesting disrupted stimulus evaluation and
memory retrieval processes. The endogenous P3 potentials discriminated
between task conditions but without further differences between groups.
These results suggest that the observed impairments in task-switching
behavior were not specifically related to anticipatory set-shifting, but
derived from a deficit in the implementation of task-set
representations at target onset in the presence of irrelevant and
conflicting information.


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