Quantitative magnetoencephalography of spontaneous brain activity in alzheimer disease

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Publication Details

Subtitle: An exhaustive frequency analysis
Author list: Fernández, A., Hornero, R., Mayo, A., Poza, J., Maestú, F., Ortiz Alonso, T.
Publisher: Lippincott, Williams & Wilkins
Publication year: 2006
Volume number: 20
Issue number: 3
Start page: 153
End page: 159
Number of pages: 7
ISSN: 0893-0341
Languages: English-Great Britain (EN-GB)


Quantitative magnetoencephalography (qMEG) was used to investigate
differences in the 2 to 60 Hz spectral power, between Alzheimer disease
(AD) patients and control subjects. Twenty-two AD patients and 21
age-matched control subjects participated in this study. MEG signal
analysis comprised the division of the entire 2 to 60 Hz spectrum in 2
Hz-width subbands. Both the relative power and the contribution of each
subband to the correct classification of AD patients and controls were
calculated. The relative power in 2 bands comprised between 2 to 4 Hz
and 16 to 28 Hz was selected by a restrictive multiple-comparison test,
among the entire 2 to 60 Hz spectrum. Using 2 to 4 Hz values it is
possible to choose a classification rule with an estimate sensitivity
and specificity given by 68% and 76% respectively. Alternatively, when
16 to 28 Hz values are used, it is possible to obtain a better
classification rule with an estimate sensitivity and specificity given
by 81% and 80%, respectively. To the best of our knowledge, this is the
first electroencephalography or MEG study where a so exhaustive analysis
of the magneto-electric spectrum has been performed. This study
supports the notion that more attention should be devoted to the study
of β band in AD. Copyright © 2006 by Lippincott Williams & Wilkins.


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Last updated on 2019-13-08 at 00:16