Synthesis of 2-alkyl-3-hydroxy-4-pyridinone-ribonucleosides, potential oral iron chelators

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Publication Details

Author list: Liu G, Bruenger FW, Barrios AM, Miller SC
Publication year: 1995
Journal: NUCLEOSIDES & NUCLEOTIDES (0732-8311)
Volume number: 14
Issue number: 9-10
Start page: 1901
End page: 1904
Number of pages: 4
ISSN: 0732-8311
Languages: English-Great Britain (EN-GB)


Abstract

Several ribonucleosides, named 2-alkyl-3-hydroxy-1-(beta-D-ribofuranosyl or pyranosyl)-4-pyridinones, were synthesized in good yield. The method provides a useful means to obtain alpha-ketohydroxypyridin derivatives with different sugar moieties that, if used as drugs, might enhance their absorption from the intestine and certain other desirable pharmacological properties.


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Last updated on 2019-23-08 at 11:15