EFFECT OF SOME BISBENZYLISOQUINOLINE ALKALOIDS ON AMERICAN LEISHMANIA SP IN BALB/C MICE

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Liste des auteurs: FOURNET A, BARRIOS AA, MUNOZ V, HOCQUEMILLER R, CAVE A
Editeur: Wiley: 12 months
Année de publication: 1993
Numéro du volume: 7
Numéro de publication: 4
Page d'accueil: 281
Dernière page: 284
Nombre de pages: 4
ISSN: 0951-418X
Languages: Anglais-Royaume-Uni (EN-GB)


Résumé

Four bisbenzylisoquinoline alkaloids, antioquine, berbamine, gyrocarpine and isotetrandrine were tested in BALB/c mice infected with Leishmania amazonensis (IFLA/BR/67/PH8 or MHOM/GF/84/CAY-H-142) or L. venezuelensis (VE/74/PM-H3). The treatments were initiated 1 day after the parasitic infection, with alkaloid at 100 mg/kg/day for 14 days and the reference compound, meglumine antimonate (Glucantime(R)) at 200 mg/kg/day. Antioquine, berbamine and gyrocarpine were less potent than Glucantime against L. amazonensis (PH8). Only isotetrandrine exhibited activity approximately equal to or greater than Glucantime in BALB/c mice infected with L. amazonensis (PH8 or H-142) and showed significant activity against L. venezuelensis. Experiments with a single local treatment on the footpad, 2 weeks after parasitic infection with L. amazonensis (PH8), showed that isotetrandrine at 200 mg/kg was less active than Glucantime at 400 mg/kg.


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