EFFECT OF NATURAL NAPHTHOQUINONES IN BALB/C MICE INFECTED WITH LEISHMANIA-AMAZONENSIS AND L-VENEZUELENSIS

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Publication Details

Author list: FOURNET A, BARRIOS AA, MUNOZ V, HOCQUEMILLER R, CAVE A
Publisher: GEORG THIEME VERLAG
Publication year: 1992
Journal: TROPICAL MEDICINE AND PARASITOLOGY (0177-2392)
Volume number: 43
Issue number: 4
Start page: 219
End page: 222
Number of pages: 4
ISSN: 0177-2392
Languages: English-Great Britain (EN-GB)


Abstract

Plumbagin, 3,3'-biplumbagin and 8,8'-biplumbagin are naphthoquinones isolated by activity-directed fractionation from a Bolivian plant, Pera benensis, used in folk medicine as treatment of cutaneous leishmaniasis caused by Leishmania braziliensis. BALB/c mice were infected with L. mexicana or L. venezuelensis and treated 24 h after the parasitic infection with plumbagin (5 or 2.5 mg/kg/day), 3,3'-biplumbagin, 8,8'-biplumbagin (25 mg/kg/d) or Glucantime(R) (200 mg/kg/d). Lesion development was the criteria employed to evaluate the inhibitory effect. The bisnaphthoquinones were less potent than Glucantime against L. amazonensis and L. venezuelensis. Plumbagin and Glucantime delayed the development of L. amazonensis and L. venezuelensis. Assays of a single local treatment on footpad infection two weeks after the parasitic inoculation with L. amazonensis showed that 8,8'-biplumbagin (50 mg/kg/d) was as potent as Glucantime (400 mg/kg/d).


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