Neuropsychological profiling of impulsivity and compulsivity in cocaine dependent individuals

Journal article


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Publication Details

Author list: Fernández-Serrano M.J., Perales J.C., Moreno-López L., Pérez-García M., Verdejo-García A.
Publisher: Springer Verlag (Germany)
Publication year: 2012
Volume number: 219
Issue number: 2
Start page: 673
End page: 683
Number of pages: 11
ISSN: 0033-3158
Languages: English-Great Britain (EN-GB)


Abstract

RATIONALE:

Research on the relative impact of trait
impulsivity vs. drug exposure on neuropsychological probes of response
inhibition vs. response perseveration has been posited as a valid
pathway to explore the transition between impulsivity and compulsivity
on psychostimulant dependence.

OBJECTIVES:

The objectives
of this study are to examine performance differences between
cocaine-dependent individuals (CDI) and healthy comparison individuals
(HCI) on neuropsychological probes of inhibition and perseveration and
to examine the predictive impact of trait impulsivity-a proxy of
premorbid vulnerability, and severity of cocaine use-a proxy of drug
exposure, on CDI's performance.

METHODS:

Forty-two CDI
and 65 HCI were assessed using the UPPS-P Scale (trait impulsivity), the
Stroop and go/no-go (inhibition) and revised-strategy application and
probabilistic reversal tests (perseveration).

RESULTS:

CDI,
compared to HCI, have elevated scores on trait impulsivity and perform
significantly poorer on inhibition and perseveration, with specific
detrimental effects of duration of cocaine use on perseveration.

CONCLUSIONS: CDI
have both inhibition and perseveration deficits; both patterns were
broadly indicative of orbitofrontal dysfunction in the context of
reinforcement learning. Impulsive personality and cocaine exposure
jointly contribute to deficits in response perseveration or compulsivity


Keywords

Addiction, Cocaine, Compulsivity, Drug use severity, Impulsivity, Response inhibition, Response perseveration


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Last updated on 2019-13-08 at 00:15