Negative mood induction normalizes decision making in male cocaine dependent individuals

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Author list: Fernández-Serrano M. J, Moreno-López L., Pérez-García M., Viedma-Del Jesús M.I., Sánchez-Barrera M.B., Verdejo-García A.
Publisher: Springer Verlag (Germany)
Publication year: 2011
Volume number: 217
Issue number: 3
Start page: 331
End page: 339
Number of pages: 9
ISSN: 0033-3158
Languages: English-Great Britain (EN-GB)


Abstract

RATIONALE:

Decision making is thought to play a
key role in psychostimulant relapse, but very few studies have
addressed the issue of how to counteract decision-making deficits in
addicted individuals. According to the somatic marker framework,
pervasive decision-making problems in addicted individuals may relate to
abnormalities in the processing of emotional signals that work to
anticipate the prospective outcomes of potential decisions.

OBJECTIVE:

The
present study was conducted to test whether the induction of different
emotional states (positive, negative, or drug-related) could either
normalize or further impair decision-making performance in male cocaine
polysubstance-using individuals (CPSI), as indexed by the Iowa gambling
task (IGT).

METHODS:

Forty-two CPSI and 65 healthy
control individuals (all males) were randomly allocated in four
affective conditions using a parallel-group design. Participants in the
different conditions performed the IGT during exposure to neutral,
positive, negative, or drug-related sets of affective images.

RESULTS:

The
results showed that the CPSI exposed to the negative affective context
showed a preference for the risk-averse safe choices of the IGT and had a
net performance indistinguishable from that of controls. On the other
hand, CPSI exposed to positive, drug-related, and neutral contexts
showed the typical pattern of disadvantageous performance in the IGT and
performed significantly poorer than controls. The impact of the
negative mood induction could not be explained in terms of baseline
differences in decision-making skills, personality traits related to
sensitivity to reward/punishment, or trait positive/negative affect.

CONCLUSIONS:

We
conclude that negative mood induction can normalize decision-making
performance in male CPSI, which may have important implications for the
treatment of cocaine use-related disorders.


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Last updated on 2019-13-08 at 00:15